The different faces of inorganic elements in SARS-CoV-2 infectionArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 치료제, [키워드] Abstract COVID-19 element elements SARS-CoV-2 SARS-COV-2 infection toxic Toxic elements trace Trace elements. [DOI] 10.1016/j.jtemb.2022.127083 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trialsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19 [DOI] 10.1007/s00228-022-03380-5 PMC 바로가기
Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine stormArticle Published on 2022-10-102022-11-16 Journal: NPJ Systems Biology and Applications [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute respiratory distress agonists Antimicrobials approach approved drugs automated biological pathway candidate drug Combination competing complex Compound compounds COVID-19 infection Cytokine storm Dexamethasone disrupt downstream interaction driving drug drug combination Drug discovery drugs drugs targeting dysregulation Effects element engage functional Host host immune system identify immune in silico Approach Interaction Intervention less mTOR inhibitor other disease peer-reviewed predicted Regulatory scored signaling cascade significantly subset suppressor syndrome target while [DOI] 10.1038/s41540-022-00250-9 PMC 바로가기
A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion systemArticle Published on 2022-10-012022-11-15 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] administration Analysis antibody Antigen antigens attenuated Salmonella ΔhtrA-VNP Bacterial caused CD44 CD69 COVID-19 vaccine cytometric cytosol delivery effective element elicited Express expression Flow fluorescence microscopy Heterologous IgA IgG in vitro increase in Macrophage mixed bacterial preparations. mutant N-protein NTD Oral vaccine pathogenicity phenotype Plasmid promoter RBD S-protein Safe Salmonella SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine screened secrete secretion shown Significance Significant significant increase SPI-2 strain T-cell activation T3SS the vaccine type III Vaccine was used [DOI] 10.1111/jam.15720 PMC 바로가기
Evaluation of Lactocare® Synbiotic Administration on the Serum Electrolytes and Trace Elements Levels in Psoriasis Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial StudyRandomized Controlled Trial Published on 2022-10-012022-10-05 Journal: Biological trace element research [Category] 임상, [키워드] administration affected Analysis baseline baseline levels blood sample clinical collected compensated control group COVID-19 Effect Electrolyte element gastrointestinal tract groups IMPROVE intervention group investigated Level Mild mineral absorption moderate oxidative stress Patient patients Placebo Probiotic psoriasis randomly divided serum Serum level Sex significant difference significantly significantly higher significantly increased significantly lower Support the patient the placebo group trace Trace element trace element. trace elements Treatment treatment group was performed were measured [DOI] 10.1007/s12011-021-03020-6 PMC 바로가기 [Article Type] Randomized Controlled Trial
Molecular and Structural Analysis of Specific Mutations from Saudi Isolates of SARS-CoV-2 RNA-Dependent RNA Polymerase and their Implications on Protein Structure and Drug-Protein BindingArticle Published on 2022-10-012022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Affect approaches binding energy caused collected conformational Coronavirus-2 COVID-19 COVID-19 pandemic develop effort element health system information Interaction isolate molecular Molecular dynamics simulation morbidity and mortality mutant RdRp mutants Mutation mutations mutations. Pandemics Protein protein stability RdRP Remdesivir RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 RdRp sequence SARS-CoV2 Saudi Arabia secondary structure significant level Specific Structure therapeutic variety virus wild type wild-type Wuhan, China [DOI] 10.3390/molecules27196475 PMC 바로가기
Increases in symptoms of depression and anxiety in adults during the initial phases of the COVID-19 pandemic are limited to those with less resources: Results from the Lifelines Cohort StudyResearch article Published on 2022-10-012022-10-05 Journal: Journal of psychiatric research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] age agency And personality Anxiety anxiety symptoms association average baseline Capital class condition COVID COVID-19 COVID-19 cohort COVID-19 pandemic Depression element ENhance finding Health health condition increase increase in individual individuals initial Latent less maintain mental health MOST number of symptom obesity Odds ratio predicted Probability ranged receive reported reporting symptom Research resource Result socioeconomic status subsequent Symptom symptoms of depression the mean trajectory unlikely were used [DOI] 10.1016/j.jpsychires.2022.07.011 [Article Type] Research article
Microfiber releasing into urban rivers from face masks during COVID-19COVID-19 동안 안면 마스크에서 도시 강으로 방출되는 극세사Article Published on 2022-10-012022-09-11 Journal: Journal of environmental management [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggravate Analysis aquatic environment cause Contamination coronavirus disease COVID-19 COVID-19 pandemic density element Epidemic evaluate expected face Face mask Face masks immersion investigated Mask Medical waste management Microfiber Occurrence plastic Plastic degradation potentially toxic Prevent protective role Public Public awareness raise released Respirator river River management SEM SEM analysis. significantly higher Spread spread of COVID-19 Tear tested Transport vector water wear wear and tear [DOI] 10.1016/j.jenvman.2022.115741 PMC 바로가기 [Article Type] Article
Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesisArticle Published on 2022-10-012022-11-16 Journal: Experimental & Molecular Medicine [Category] 변종, 유전자 메커니즘, [키워드] analysis ChIP chromatin chromatin architecture classical monocytes clinical impact COVID-19 dissect element exacerbating exhibited facilitate Gene Expression gene expression signature Hematopoiesis highlight hyperinflammation IFN-γ immunological individual Inflammation inflammatory immune response Inflammatory responses interactions mechanism methylated mononuclear cells Patient Peripheral blood putative target gene Region Regulatory reported severe COVID-19 severe COVID-19 patients severity single-cell susceptibility Transcriptome with COVID-19 [DOI] 10.1038/s12276-022-00866-1 PMC 바로가기